Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg 341 SMILES O=C1N(CC2=C(NCCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC)

341 SMILES O=C1N(CC2=C(NCCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

577 Purity (HPLC) >= 95% Solubility DMSO

492 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCCOCC#C Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

677 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg 341 SMILES O=C1N(CC2=C(NCCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating